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Addl. Prof.
Physiology| Degree / Diploma | Name of the University/ Institution | Subject | Year of Passing |
|---|---|---|---|
| PhD | 2009 | Physiology | DIPAS, Delhi |
Research Areas:
My research interest pertains to basic and applied approaches for understanding and mitigating cognitive impairment and depression related disorders through a ‘Systems Biology’ and ‘Man to Molecule’ approach. Some of the research activities being undertaken by our team through Intra-Mural and Extra-Mural funded projects are as under
My research team focuses on understanding molecular signalling mechanisms that govern the survival and death responses of neuronal cells under hypoxic stress. Upstream signalling mechanisms that regulate Hif-1 alpha and Nrf-2 mediated survival responses as well as apoptotic and necrotic cell death pathways during hypoxic stress can be potential therapeutic targets for rescuing neuronal cells from hypoxic cell death during ischemia and stroke. We elucidate these signalling mechanisms using in vitro models of hypoxia.
Understanding brain responses and underlying physiological mechanisms associated with comorbid depression has been another area of my research interest. The association of physiological factors like arterial stiffness and cerebro-vascular coupling with comorbid depression are being studied to identify possible non-invasive physiological interventions like activity induced brain plasticity for treatment of depression.
Understanding physiological responses elicited by environmental stressors and the innate ability of human physiology to adjust to these stressors is the key to devising prophylactic approaches for improved endurance. My team is attempting to understand the role of specific bio molecules and ions that can prevent heat stress induced RBC fragility and heme toxicity through regulation of gardos channels.
Investigating the potential of nutraceuticals and natural adaptogens to ameliorate stress induced alterations in human physiology is an important area of research being pursued in my lab. We have identified cardioprotective and anti-hypertensive potential of Seabuckthorn seed oil and prophylactic potential of salidroside in rhodiola root during hypoxic stress.
Research Areas:
My research interest pertains to basic and applied approaches for understanding and mitigating cognitive impairment and depression related disorders through a ‘Systems Biology’ and ‘Man to Molecule’ approach. Some of the research activities being undertaken by our team through Intra-Mural and Extra-Mural funded projects are as under
My research team focuses on understanding molecular signalling mechanisms that govern the survival and death responses of neuronal cells under hypoxic stress. Upstream signalling mechanisms that regulate Hif-1 alpha and Nrf-2 mediated survival responses as well as apoptotic and necrotic cell death pathways during hypoxic stress can be potential therapeutic targets for rescuing neuronal cells from hypoxic cell death during ischemia and stroke. We elucidate these signalling mechanisms using in vitro models of hypoxia.
Understanding brain responses and underlying physiological mechanisms associated with comorbid depression has been another area of my research interest. The association of physiological factors like arterial stiffness and cerebro-vascular coupling with comorbid depression are being studied to identify possible non-invasive physiological interventions like activity induced brain plasticity for treatment of depression.
Understanding physiological responses elicited by environmental stressors and the innate ability of human physiology to adjust to these stressors is the key to devising prophylactic approaches for improved endurance. My team is attempting to understand the role of specific bio molecules and ions that can prevent heat stress induced RBC fragility and heme toxicity through regulation of gardos channels.
Investigating the potential of nutraceuticals and natural adaptogens to ameliorate stress induced alterations in human physiology is an important area of research being pursued in my lab. We have identified cardioprotective and anti-hypertensive potential of Seabuckthorn seed oil and prophylactic potential of salidroside in rhodiola root during hypoxic stress.
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